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Most supplements are designed to be taken every day. Multivitamins should be taken in the same amount daily. Creatine is meant to be taken daily, although most people cycle off it sometimes. One type of supplement that can be reduced on non-workout days is the kind that provides calories, which would include protein supplements. It's important to read the label and use supplements as directed, so if something is designed to be taken before or after workouts and you don't work out that day, you can skip the supplement.